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GDF15 regulates the metabolic pathways of macrophages, acquiring an anti-inflammatory function dependent on oxidative phosphorylation, reducing the expression of pro-inflammatory factors, and decreasing the infiltration of monocytes and neutrophils into the liver, thereby alleviating liver inflammation [174, 175]

On neutrophil activation, the PPP is promoted, alongside glycolysis, to supply NADPH for antibacterial activity

doi:10.1515/BC.2009.033 Samiec PS, Drews-Botsch C, Flagg EW, Kurtz JC, Sternberg P, Reed RL, et al

They are periodically replaced by a single layer of basal keratinocytes, which proliferate constantly and give birth to cells that ascend toward the skins surface

These are short-chain carbohydrates that are not easily absorbed by the small intestine and therefore easily ferment in the colon and cause bloating

VIC can be accumulated in different tissues (e.g., brain, liver, skeletal muscles, corneal epithelium, neutrophile, stem cells) via specific transporters, and it can enhance cellular functions [5,6,7,8]