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Br J Nutr 110(8):13571368

1 Sm TG extracted from the BY4741-TG strain was used

Subsequent mutational analysis of a Drosophila GPx ( Dm GPx) also suggests a function for a conserved Asn residue that is necessary for the enzymatic function of the GPxs (361)

Inhibition of the Xc- transport system by genetic (siRNA, CRISPR) or pharmacological means (Erastin, Sulfasalazine) impairs cystine transport and GSH synthesis, leading to the inactivation of GPX4 and induction of ferroptosis [14]

OCSCs drive the polarization of macrophages into an immunosuppressive M2-like phenotype, characterized by increased CD206 expression, via the secretion of WNT ligands and cytokines like IL-10