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This results in a toroidal structure, where the lipids are significantly distorted

At very high oral doses (54 mg), gastrointestinal side effects increased significantly

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This analysis revealed the decreased surface area to volume ratio and disorganized cristae contribute to the mitochondrial dysfunction during NAFLD development, but unfortunately authors did not make comparisons between zones in the lobule

doi: 10.1016/j.ijpharm.2011.08.026 119

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