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Due to the sex-specific social and cognitive impairment in female mice, we posited that TDP-43 accumulation would reflect the behavioural changes

Hence, in situations of excess iron in the body, PUFA supplementation could hypothetically trigger ferroptosis

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Along with these functional declines, the cerebral levels of neurotransmitters such as dopamine (Wenk et al., 1989), acetylcholine (Gottfries, 1990), serotonin (Gottfries, 1990), and norepinephrine (Mei et al., 2015), and neurotrophic factors such as brain-derived neurotrophic factor (BDNF) (Terry et al., 2011) and nerve growth factor (NGF) (Zeng et al., 2011) are dramatically reduced in aging brains

The Fenton reaction generates highly reactive hydroxyl radicals

Common user-reported side effects remain generally mild when they occur at all