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Supplementation with vitamin B12, B6, and folic acid resulted in the reduction of homocysteine and oxidative stress (Stroes et al

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Redox properties of tryptophan metabolism and the concept of tryptophan use in pregnancy

Bohl CH, Volpe SL

Macrophage or dendritic cell-derived IL-12 drives the expression of IFN in nave T cell, and both IL-12 and IFN upregulate the expression of transcription factor T-bet, which is responsible for differentiation of nave T cells into Th1 cell, as illustrated in Supplementary Figure 2B (70, 72)