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The methodologic design of the rescue arm favors the sq methotrexate group, in that, on average, approximately 10% of the subjects in this group received a 25% higher dose of methotrexate than did those in the oral group (who could never receive a dose higher than 15 mg as part of the protocol)

According to Healthline , additional studies have shown that over a ten-year period, people supplementing with vitamin B12 gained between two-and-a-half to seventeen fewer pounds than those who did not take the vitamin

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