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doi: 10.3390/cancers17061039

BY: Writing original draft

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K.MeinekeI.Godtel-ArmbrustU.BrockmollerJ.WojnowskiL.2006Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1.19577586 46

Dysregulation of this pathway through altered dimerization, post-translational modifications, or impaired regulation contributes to the pathophysiology of Alzheimers disease, Parkinsons disease, Huntingtons disease, and amyotrophic lateral sclerosis, leading to protein aggregation, mitochondrial dysfunction, and neuroinflammation