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podra surgir tolerancia (aunque algunos sugieren que no provoca tolerancia fcilmente, esto no es consenso)

10.1016/j.bbrc.2016.03.052 132 XieY.ZhuS.SongX.SunX.FanY.LiuJ.et al (2017)

[117] Telephone interview with LeeAnne Walters, October 2016

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This implies that the FOXO4-p53 interaction effectively induces cellular senescence