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Thus, the determination of GSNO can be affected by light, metal-catalyzed GSNO decomposition, enzymatic degradation as a result of endogenous GSNO reductase activity and a reduction in the S -NO bond caused by reductants and endogenous thiols

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EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells

Beyond its established roles in apoptosis, p53 can also modulate ferroptosis through metabolic and redox regulatory programs

10.1038/s41392-022-01229-y 28 ChenP.ChenZ.HouW.YuL

The paper demonstrates that, despite heterogeneous expression, basal AR activity is required for sustained melanoma cell proliferation and tumorigenesis with the AR protein bridging transcription and transcription-coupled DNA repair