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We observed that GLP-1MK-801 has similar receptor signalling properties at the GLP-1 receptor compared to the parent GLP-1 analogue as well as to the pharmacokinetically optimized GLP-1 receptor agonists semaglutide and liraglutide (Extended Data Fig

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Fasting glucose reductions also favored tirzepatide (approximately -68 mg/dL vs -59 mg/dL)