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Biologic therapies such as Adalimumab (the first FDA-approved biologic for HS) [221,222,223], and Infliximab bind to and block the activity of TNF-, a major pro-inflammatory cytokine highly upregulated in HS lesions [224] (Fig

Anti-IGF-1 receptor (IGF-1R) monoclonal antibodies (mAbs) were developed for clinical use in treating advanced stage cancers 22,23,24 , including Ganitumab, which remains under investigation as a combination therapy in clinical trials targeting Rhabdomyosarcoma (NCT03041701) and Ewing Sarcoma (NCT02306161), for which it recently received orphan drug status

Phytochemistry 69 , 31593165 (2008)

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This process underscores the central role of epigenetic regulation in mediating adaptive responses in cancer cells [18]