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Fiber is considered an essential nutrient

Although the exact molecular mechanism of the dual regulation of ferroptosis by butyrate has not been fully elucidated, accumulating experimental evidence gradually suggests that it may be involved in the pathophysiological regulation of OA by regulating the ferroptosis process of chondrocytes

Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways

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These reactive astrocytes exhibit altered behaviors that can both support and disrupt neuronal function, creating a complex environment that accelerates neurodegeneration

Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicenter randomized controlled trial