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Description

Poe FL, Corn J

regulates tumor necrosis factor (TNF) and IL6 production posttranscriptionally by phosphorylating AUrich elements (AREs)binding proteins ELAVL1, HNRNPA0, PABPC1, and TTP/ZFP36, leading to increased stability and translation of TNF and IL6 mRNAs

Without exposure of the lamina propria to gliadin and the prevention of gliadin and gliadin fragments from entering into systemic circulation, the inflammatory immune reaction typically seen in patients with celiac disease can be averted

PMID: 37921175

However, the systemic introduction of ARA-290 in OIR mice seemed to lower the levels of pro-inflammatory cytokines like IL-1 and TNF- in the retinal tissue, hinting at its possible anti-inflammatory properties