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of this final rule with comment period, we are removing the FCHE measure beginning with the CY 2025 reporting period/CY 2027 payment determination

Early Cellular-Level Changes (Preclinical Findings) The earliest documented changes occur at the molecular level, within hours of receptor binding, and are not observable without laboratory measurement

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47,48 However, notably, recent findings in FitzGeralds group showed that the most commonly applied LC-MS/MS approach to SPM detection has been shown to be fundamentally flawed, especially in the analytical methods and experimental conclusions