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Targeting autocrine CCL5-CCR5 axis reprograms immunosuppressive myeloid cells and reinvigorates antitumor immunity

2019 Oct 15;79(20):5191-5203

Quick takeaway: Researchers have not established BPC-157 as a reliable, direct weight-loss tool in humans

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E.WangX.LiS.LiX

CB-1158 could block myeloid cell-mediated inhibition of T cell proliferation, increase the number of tumor-infiltrating CD8 + T cells and NK cells, and increase the expression of inflammatory factors and interferon-, thereby changing the immune microenvironment to promote inflammation and reduce tumor immune escape, inhibiting tumor cell proliferation