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Rgle simple : toute dose apporte en une seule prise, via lalimentation, qui dpasse la capacit de saturation du facteur intrinsque, sera trs mal absorbe

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Therefore, out of the many mechanisms that were suggested of how metformin interferes with the absorption of vitamin B 12 , metformin antagonism of the calcium cation and interference with the calcium-dependent IF-vitamin B 12 complex binding to the ileal cubilin receptor was the most accepted one

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