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[5], [6], [7] Transcription factors of the FOXO family specifically FOXO1, FOXO3, FOXO4, and FOXO6 are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes

View source Journal of Physiology Paris 2003 PMID 12735993 Sikiric S et al

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Over time, that can lead to fatigue, irritability, poor concentration, and even increased risk for chronic health conditions like heart disease and diabetes

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