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The brain is especially sensitive to oxidative stress because it consumes a large amount of oxygen relative to its size and contains lipid-rich membranes that can be vulnerable to oxidation

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Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+

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GPX7 can utilize the H 2 O 2 produced by Ero1 to accelerate the oxidative folding process of proteins in vitro and in vivo (Wang et al., 2014) (Figure 6)