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The MWDS paradigm models vicarious trauma relevant to chronic human stress [20, 44, 45], while daily 2 mg/kg THC from gestational day 3 to birth simulates moderate, clinically relevant exposure without inducing cannabinoid tetrad effects [46, 47, 48]

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Therapeutic potential exists in targeting necroptosis markers (RIPK1, RIPK3, and MLKL) and IFN- signaling

Biomarker-based patient selection, such as circulating oxidative stress markers (e.g., MDA, 8-OHdG), remains speculative and has not been integrated into trial designs

Mice were housed in appropriate cages with twelve wake-light/sleep-dark cycles and an ambient temperature of 25 0.5 C