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Studies on NOX4 have also revealed that its mediation of mitochondrial biogenesis in lung fibroblasts appears to be independent of PGC-1, as it can directly regulate NRF1 without involving PGC-1 ( 3 COPD The World Health Organization (WHO) has reported that COPD caused 3.22 million deaths worldwide in 2019, which represents an increase of 17.5% from 2007 to 2017, the major burden of COPD deaths occurs in Latin America, sub-Saharan Africa, India, Southeast Asia, and China (Figure 1)

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