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Also, when blood-brain barrier (BBB) is disrupted by stroke and other brain diseases, it helps to transfer the systemic iron pool into neurons in the brain parenchyma, exacerbating ferroptosis (DeGregorio-Rocasolano et al., 2019)

DOI: 10.1056/NEJM199407213310304, VOL

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Interestingly, a positive feedback loop could also be established between p38 MAPK and oxidant species, since this kinase can promote the increase in ROS levels (Borodkina et al., 2014), and oxidant species have been shown to activate p38 MAPK in senescent cells (Marmisolle et al., 2017)

Cooperation with other antitumour therapies Radiotherapy Although there is some controversy regarding the survival benefit of this technique, radiation therapy has been used to treat borderline resectable PDAC, providing the possibility of resection [262]