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It also helps modulate GABA, a calming neurotransmitter that prevents overstimulation in the brain

In Parkinsons disease (PD), astrocytic mitochondrial dysfunction disrupts the clearance of -synuclein through the ubiquitin - proteasome system and autophagy pathways, promoting the formation of Lewy bodies

Furthermore, EGCG protects cardiomyocytes from I/R-induced injury by inhibiting signal transducer and activator of transcription 1(STAT1) activation, which is associated with hemodynamic recovery and improved ventricular function in rat hearts subjected to I/R [204]

Vandenberghe et al reported that CYP2D6 but not NR1/2 , POR , PPAR , ABCB1 , CYP3A plays an important role in risperidone, 9-hydroxyrisperidone, and active moiety plasma concentration

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This allowed us to explore the potential effects of genetic variants on nearby genes and regulatory elements, providing a broader understanding of the genetic architecture underlying the trait of interest