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Oxygen (O 2 ) tension is one of the major sources that lead to oxidative stress [7]

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doi: 10.3390/ijms24065981

Additionally, the dense cartilage ECM and rapid synovial fluid turnover hinder exosome retention and uptake

These DAMPs bind to pattern-recognition receptors on antigen-presenting cells, which in turn activate the adaptive immune response

This hydrogel effectively scavenges ROS and alleviates inflammation-driven disc degeneration