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Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration

148,157,158 Specifically, some cancer cells, such as PDAC and CRC cells, depend on a noncanonical glutamine metabolism pathway in the cytosol under the regulation of oncogenic KRAS activation

Online First: 20130529] Kassebaum NJ, Bernabe E, Dahiya M et al (2014) Global burden of severe periodontitis in 19902010: a systematic review and meta-regression

(1996) Biological and biochemical inhibitors of the NF-kB/rel proteins and cytokine synthesis

However, the high-iron diets or depletion of GPX4 promotes Hydroxyguanosine 8 (8-OHG) release and thus activates the TMEM173/STING-dependent DNA sensor pathway, which results in macrophage infiltration and activation during Kras-driven PDAC in mice ( An emerging oncoprotein, Myoferlin, controls mitochondria structure and respiratory functions, has been associated with a low survival in several cancer types including PDAC