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However, if someone already has extremely high levels of vitamin B (from taking excessive supplements and showing toxicity symptoms), further pyridoxine would be avoided

Key accelerators of this breakdown include: Neuroinflammation: Cytokines from Lyme, Long COVID, or concussion damage synaptic connections.[5] Mitochondrial dysfunction: Energy factories in cells fail, starving muscles and brain of ATP.[6] Disrupted proprioception: The body loses its internal GPS, leading to imbalance and falls.[7] Sympathetic overdrive: Chronic fight-or-flight traps patients in pain/fatigue cycles.[8] Muscle atrophy: Inactivity after injury or illness causes rapid loss of strength and stability.[9] These create a vicious feedback loop

4.1 Neural communication The vagus nerve connects the GI tract and the brain, influencing both neurochemical and inflammatory communication along the gut-immune-brain axis

The data is clear on this point