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Rather, they often present concurrently, in varying severity, and are intertwined with and influence each other (Figure 1)

These differentially methylated CpG-related genes are highly enriched in biological processes related to DPN progression, such as neurodevelopment, neuronal development and axon guidance, glycerophospholipid metabolism, and mitogen-activated protein kinase (MAPK) signaling

Unfortunately, many of these tools still need large training data or further adjustments for detection improvement [28], while they are also able to detect only specific DNA methylation patterns (e.g

Central vagal circuits that control glucose metabolism

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It could lead to a higher risk of cancer