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The trigeminal route includes transport along different branches of the trigeminal nerve that innervate the nasal respiratory mucosa: the ethmoidal nerve originating from the ophthalmic nerve, as well as the posterior nasal branches and the nasopalatinal nerve originating from the maxillary nerve [42, 43]

However, it's not clear how effective this approach would be

doi: 10.1158/0008-5472.CAN-14-2156 387 ShouzuANomuraSOmotoSHayakawaTNishikawaMIwasakaT

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Most published findings originate from cell-based studies and animal models

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