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Studies have demonstrated that Nrf2-EpRE pathway is involved in both the basal and inducible expression of GCL genes [25]

The Yoon group also recently reported the QG-1 probe, which is structurally similar to our RT prototype TQG-CN (Fig

"I believe vitamins E and C are important as part of our antioxidant defenses, even if we have not yet documented specific preventive effects," says Weil

[DOI] [PMC free article] [PubMed] [Google Scholar] Kiddle G, Pastori GM, Bernard B, Pignocchi C, Antoniw J, Verrier PJ, Foyer CH

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Beyond classical antioxidant signaling, GSH interfaces with additional pathways, including Hippo-Yes1 associated transcriptional regulator (YAP1) signaling to regulate GPX4 and SLC7A11 expression, 159,160 mechanistic target of rapamycin kinase (mTOR) signaling to influence GPX4 protein synthesis through cysteine metabolism, 161 and NF-B signaling to restrain inflammation-associated ROS production 162