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Moreover, statistical analyses were not adjusted for potential confounding other than stratification by sex, TDF and/or EFV use, and INSTI and TAF use combination, as well as restriction to individuals maintaining the same combination of INSTI and TAF use before and after switch

Only the first 36 months of follow-up were analyzed due to the insufficient number of data points beyond 36 months in this subset of the population

By reducing nicotinamide methylation, supports cellular NAD+ availabilitya critical coenzyme for mitochondrial function, energy metabolism, and cellular repair

Regular supplementation can improve focus, mental clarity, and overall mood, reducing symptoms of anxiety and depression linked to B12 deficiency

This is a conceptual overview of why multi-compound research designs exist, not a protocol or combination guide

B 13 , 709721 (2023)