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miR-122a was shown to mediate TNF-induced barrier leakage, while miR-223 upregulation in enterocytes resulted in the reduction of CLDN8

[DOI] [PubMed] [Google Scholar] Fasano M., Curry S., Terreno E., Galliano M., Fanali G., Narciso P., et al

The methanolic extract was also found to be more protective in comparison with the chloroform extract, which might be due to the lipophilic nature of pomegranate constituents [12]