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Similarly, selenium, another trace element, has shown promise in PCa treatment

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Pediatrics 1969;43:463-5

Third, the metabolomic profile in patients is significantly confounded by factors such as concomitant medications (particularly glucocorticoids), comorbidities, and diet, making it essential to disentangle these effects to identify disease-specific metabolic signatures (148)

Paradoxically, liver-specific FASN knockout promoted hepatic steatosis in mice on a zero-fat diet [60], in which steatosis developed alongside defective PPAR signaling and with a phenotype that could be corrected by dietary fat or a PPAR agonist [60]