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Most of the research has been in animals or labs, not humans, says Paul Knoepfler, a cell and molecular biologist at University of California, Davis

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That distinction, between restoration and enhancement, between evidence and enthusiasm, is where the serious work of longevity medicine is being done

RB1 loss links to increased mitochondrial OXPHOS, which links to enhanced anabolic metabolism and augmented cancer cell stemness and metastatic spread (232)