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In a renal IRI model, ALDH2 activation attenuates inflammation and decreases kidney injury by modulating the IB/NF-B/IL-17C pathway (4)

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There is some evidence to suggest that zonation associated with P450 induction is modulated by circulating levels of growth hormone and thyroid hormones, whereas the zonation of constitutive P450 expression is governed by other factors (Lindros 1997