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Warburg O, Wind F, Negelein E

20 Although p28 inhibited the binding of the RING E3 ligase Cop1 to the p53 DBD, until now, its role in the ubiquitination of p63 was not defined

BTZ may also induce autonomic neuropathy, manifesting as orthostatic hypotension and alterations in sexual and urinary function, though such cases are relatively rare (Zhang, 2021)

Complementing these findings, Mendelian randomization analyses using genome-wide association data suggest potential causal links between specific gut microbial taxa and PD risk, with effects partly mediated through inflammatory cytokines and metabolic intermediates such as tryptophan [196]