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If B12 blood levels and MMA are both high, a functional B12 deficiency could be preventing B12 being useful at cell/tissue level

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Published studies have shown that NNMT expression affects myogenic differentiation the process by which satellite cells activate, proliferate, and fuse to form new muscle fibers

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in diet-induced obese mice

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