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19 Although the mechanisms underlying endothelial dysfunction are multifactorial, a growing body of evidence suggests that increased ROS production contributes considerably to this phenomenon in several ways

Chronic stress elevates cortisol, which promotes visceral fat storage, breaks down muscle tissue, increases appetite for high-calorie foods, and impairs insulin sensitivity

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This disruption in the phagocytic clearance of apoptotic cells will likely cause chronic inflammation and weakened immune responses, potentially worsening tissue damage during infections