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Rutin has also exhibited promising results in the rat model of acetic acid-induced colitis, in which pre-treatment (25 and 100 mg/kg) resulted in significant improvements in inflammatory indicators (62)

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The compound appears to exert bidirectional influence on the NO system: upregulating endothelial nitric oxide synthase (eNOS) expression in vascular endothelium while simultaneously attenuating the pathological overactivation of inducible nitric oxide synthase (iNOS) in inflammatory contexts

Yesapply to face and neck twice daily with continued use