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The progressive sequencefrom CYP2E1 induction and ROS overproduction to ATP depletion and apoptosishighlights the bioenergetic failure underlying hepatocellular damage in this condition (Figure 2)

Plasma levels of GHK average around 200 ng/mL at age 20

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Investigation of the mechanism underlying calcium dobesilate-mediated improvement of endothelial dysfunction and inflammation caused by high glucose

10.1016/j.bbcan.2020.188338 27 ForsterF.SchullerJ

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