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By any standard, the definition of an enlarged heart in this Consensus Statement is a textbook example of pseudo-science

[1] This cycle ensures that cells maintain the optimal GSH:GSSG ratio of 10:1 to 100:1, a critical indicator of cellular health

Furthermore, GPX4 expression is regulated by multiple transcription factors, such as SP1 (Sp1 transcription factor) and TFAP2A/AP2 (transcription factor AP-2 alpha), in specific cells or conditions [9] (Figure 4A)

In contrast, MYCN-amplified cell lines exhibited radioresistance under the same conditions, suggesting that targeting Gln metabolism can be beneficial for the treatment of c-MYC-driven but not MYCN-amplified neuroblastoma [134]