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Given the expansion of the AR cistrome and the emergence of novel AR binding sites under ADT, similar to observations during carcinogenesis, it is tempting to speculate that other factors acting at or near AREs may be in play in CRPC

3 Choline is also important for normal kidney and mitochondrial function

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Also, some evidence suggests that perhaps creatine in combination with other neuroprotective nutrients (as opposed to alone, as in the NET-PD studies) might be of benefit: a recent animal study found that creatine, in combination with CoQ10, conferred significant neuroprotection by reducing the accumulation of alpha -synuclein and suppressing lipid oxidation

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