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Semaglutide can be used in people with most heart, kidney, liver, and endocrine conditions

But the window is only useful if what you are keeping (muscle mass, metabolic baseline, mood) is protected while you are using it

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Cancer Res 72(21):54735482 Colbeck EJ et al (2017) Treg depletion licenses T cell-driven HEV neogenesis and promotes tumor destruction

Niacin (nicotinic acid) in non-physiological doses causes hyperhomocysteineaemia in Sprague-Dawley rats

It also has neuroprotective influences on brain cells