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Transgenic animals engineered to overexpress -Syn are utilized to explore the role of this protein in the degeneration of dopaminergic cells (Prymaczok, et al

For inducible transcriptional downregulation, cells were infected with the hu-GCLC or hu-CAT Tet-inducible lentiviral shRNA system (Dharmacon SMARTvector, Horizon, Cambridge, UK)

The relative level of FENDRR was normalised to the average level of the IgG group ( Primer sequences for FENDRR detection: Forward: 5-CGCGGGCTTCTCTACTCTTA-3 Reverse: 5-CCTTTTACAAGCGCAGGTTC-3

Aug 1 2019;110(2):316-329

71 Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) were firstly identified as key enzymes which promote PUFAs into PLs for forming PL-PUFAs and induce ferroptosis