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Decreased blood oxidative stress after repeated muscle-damaging exercise

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Mechanism The mechanism of ferroptosis mainly includes the following three aspects: SLC7A11/GPX4 pathway (System Xc- pathway) : GPX4 utilizes a glutathione (GSH)-dependent catalytic mechanism to reduce peroxide bonds (-OO-) in lipid hydroperoxides to hydroxyl groups (-OH), thereby neutralizing their oxidative activity (Ursini and Maiorino 2020)

During physical activity, the body first uses energy from the body's fat reserves

Rapamycin delays tumor development in murine livers by inhibiting proliferation of hepatocytes with DNA damage

doi: 10.1016/j.freeradbiomed.2007.03.024 35 MillerRABritiganBE