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BBR ameliorates ovarian inflammatory responses in PCOS rat models through downregulating TLR4/lyn tyrosine kinase (LYN)/NF-B signaling and suppressing pro-inflammatory mediators (TNF-, IL-1, IL-6) via PI3K/Akt/NF-B pathway regulation, thereby suppressing immune cell infiltration and cytokine storm cascades [191]

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doi: 10.5772/intechopen.92213 82 IqbalS.IqbalM

Figure 9 Analysis of mRNA sequencing results from wild strain TPC-1 cells and RRM2 overexpression strain ( RRM2 -OE-TPC-1) showed significant enrichment of differential genes in the cell cycle pathway, as shown in Supplementary Table 4