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doi: 10.1148/radiology.219.2.r01ma12503 154 IonescuDNHuntJLLomagoDYousemSA

[DOI] [PMC free article] [PubMed] [Google Scholar] Beyer F, Kharabian Masouleh S, Kratzsch J, Schroeter ML, Rhr S, Riedel-Heller SG, Villringer A, Witte AV

It must be used as an adjunct to a reduced-calorie diet and increased physical activity

Consistent with the delay in Gal3 clearance observed above in ATXN3-deficient cells, we observed a reduced recovery of lysosomal degradative capacity after damage in ATXN3 KO cells as monitored by the fluorogenic proteolysis reporter DQ-BSA in lysosomes (Fig