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Symptoms related to folate deficiency include fatigue, apathy, insomnia, impaired concentration, and irritability (30)

Cavallaro RA, Nicchia E, Semplici B, et al

At standard doses of 1 mg or less daily, side effect rates were similar to placebo

76 In about 2% of patients, leukopenia is persistent, but even patients with WBC counts of 3,000/mm 3 (3 10 9 /L) or less do not seem to have an increased incidence of infection