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The primary pathological manifestation of impaired intestinal mucosal barrier function is altered intestinal mucosal permeability, apoptosis of intestinal epithelial cells (IECs), and disruption of intercellular TJs are the main relevant factors

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The suppression of the type I IFN response by ROS is due to oxidation of cysteine 147 of murine stimulator of IFN, an ER membrane protein that mediates the IFN response after cytoplasmic DNA sensing 59,133,134