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The activation of resident hepatic stellate cells into myofibroblasts to produce matrix proteins is the crucial step in fibrogenesis (Mederacke et al., 2013)

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These observed changes may be due not only to high fat and low carbohydrate content in the diet but also to low protein intake, since adequate protein levels are important for maintaining bone health 39

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Finally, direct oxidative modification (and inhibition) of the PTP that dephosphorylate the Src activation loop site also contribute to redox-activation of Src kinase activity ( There is limited evidence that free radicals can directly oxidize membrane phospholipids

Therefore, lipopolysaccharide translocated to the liver (as in IBD) [73] could ameliorate PSC in IBD-PSC