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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Chacko B.K., Reily C., Srivastava A., Johnson M.S., Ye Y., Ulasova E

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Concurrently, lactate accumulation contributes to an acidic tumor microenvironment that impairs T cell effector function, induces exhaustion, and suppresses proliferation [83]

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Unlike traditional peptides, this small molecule acts as a selective REV-ERB agonist , which means it influences circadian rhythm pathways and metabolic processes through a distinct mechanism