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Medical history, symptoms, and follow-up tests help clarify the cause

10.1007/PL00002139

Low body temperature (hypothermia) is also a warning, as it reflects severe impairment of the body's ability to regulate temperature

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Patients with homozygosity at this mutated locus tend to exhibit a more severe clinical phenotype, usually associated with severe mental retardation and early onset seizures, and five of them died early in life [6,7,8]